Piseco is popular among fisher-folk for lake trout and land-locked salmon. It also has a solid population of whitefish. Most of the fishing pressure is during the ice fishing season. In the spring, trout and salmon are best caught by trolling near inlets.
Look for walleye, rainbow trout, brown trout, smallmouth bass, brown bullhead, perch, rock bass, and whitefish.
There are three state campgrounds on the lake, each with a paved launch for trailers. All can be found by taking Old Piseco Road off of Route 8 on the back side of the Piseco Lake.
Piseco Lake offers some interesting side trips, such as a paddle up Fall Stream to Fall Lake. Only two miles further upstream, and several beaver dams later, is the remote Vly Lake. Big Bay is accessible from Pisceco Lake and from a parking area on Route 10.
Winter fishing species include lake trout, yellow perch, lake whitefish, smelt, and landlocked salmon.
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Piseco Lake has special regulations for ice fishing.